This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this proposed additional study is to track long-term (5-year) risk factors and the development of overt and occult coronary artery disease (CAD) in initially apparently healthy African American siblings of person with premature coronary disease. This is a complement to a newly awarded National Institutes of Health award to study this same population to determine impact of the original randomized trial of a nurse practitioner/community health educator model of lipid and blood pressure management (NURS TEAM) compared with usual primary care (UC) five years after the original intervention (1998-2001). . At baseline in the original community intervention study, a complementary study was funded by the GCRC that allowed characterization of additional risk factors and markers of occult CAD and vascular disease that now serves baseline for the prospective complementary study being proposed. A family history of premature CHD has long been known to confer marked excess CHD risk, but it only recently noted in African Americans where the prevalence of CHD risk factors is extremely high and the trajectory of the disease is not well characterized. Thus, this study will follow all original 464 siblings screened (those with and without risk factors at baseline---those without risk factors did not enter the treatment trial but we wish to track them also for incidenct CHD, new occult CHD, and changes in risk factors). The main study of long-term intervention effects is designed to examine changes over five years in lipid levels, blood pressure, body mass index, diet, physical activity, fitness, medication use, stress, health care utilization, and general well being. The additional complementary study would track changes in plasma glucose, fibrinogen, serum insulin, serum creatinine, urinary microalbunin, homocysteine, plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (tPA). In addition, left ventricular mass would again be characterized by echocardiography to prospectively examine the impact of risk factor status on increased in left ventricular mass, and the impact of left ventricular mass on clinical vascular outcomes. Importantly, incident coronary disease will be examined and occult disease will be examined using the same stress thallium scintigraphy methods used at baseline. Together, these appraisals will allow full prospective characterization of high-risk African Americans and ultimately will e the substrate for a long-term prospective epidemiologic study for which we have a matching white population of over 600 white siblings assessed using the same techniques.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Aboud, Katherine S; Barquero, Laura A; Cutting, Laurie E (2018) Prefrontal mediation of the reading network predicts intervention response in dyslexia. Cortex 101:96-106
Kattan, Meyer; Bacharier, Leonard B; O'Connor, George T et al. (2018) Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy. J Allergy Clin Immunol Pract 6:1596-1603.e6
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168
Robert Braši?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6:
Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866

Showing the most recent 10 out of 1014 publications