This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The most frequent neurologic complication of HIV infection and its treatments is distal symmetric peripheral neuropathy (DSPN.) There are no effective treatments to date for DSPN. DSPN is associated with advanced HIV disease as well as with neurotoxic dideoxynucleoside reverse transcriptase inhibitors use with ddI, ddC and d4T. Acetyl-L-carnitine (ALC) is an endogenous molecule which is ultimately involved in a number of acetylation reactions including the Krebs cycle. There is evidence that ALC has a beneficial effect regarding HIV-DSPN. This open-label dose-escalation pilot study will examine the efficacy of ALC as well as the safety and tolerability of ALC.
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