This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.CA125 is a biomarker for the presence of ovarian cancer that may identify many ovarian cancers before clinical symptoms develop. We hypothesize that for women with a high risk of developing ovarian cancer, screening for ovarian cancer or peritoneal carcinomatosis with frequent CA125 measurements and ultrasound may permit earlier detection than current practice. Such a trial would also permit initial estimation of the incidence of ovarian cancer by age and menopausal status. While not the endpoint of this pilot study, earlier detection may lead to an increased survival. A retrospective analysis of data from a randomized pilot trial of screening with CA 125 in post-menopausal women at normal risk for breast cancer indicated that using the computed mechanism: the Risk of Ovarian Cancer Algorithm (ROCA), substantially improved sensitivity and positive predictive value of using CA125 measurements to predict ovarian cancer. ROCA calculates the risk of having ovarian cancer based on the age, family history and longitudinal CA125 values.Women with a BRCA1 or BRCA2 mutation have an increased lifetime risk for ovarian cancer that is 10-20 fold higher than that of women without such mutations. As well, women with a strong family history of breast and/or ovarian cancer may also be at higher risk. These women, at an increased risk either because of a known inherited predisposition to ovarian cancer or a strong family history, are routinely screened with CA125 blood tests and/or transvaginal ultrasounds. These screening tests are used individually or in combination. This study is designed to determine the sensitivity and specificity of the effectiveness of regular surveillance using longitudinal CA125 tests in combination with transvaginal ultrasounds in detecting ovarian cancer at early stages in woman at high risk for ovarian cancer. Currently approximately 50% of women with BRCA 1 and BRCA 2 mutations undergo prophylactic oophorectomy, usually prior to natural menopause. Premature menopause increases the risk of atherosclerosis and osteoporosis. Yet, prophylactic oophorectomy is done in the absence of knowing the incidence of ovarian cancer in high risk, premenopausal women. This trial permits an initial estimation of the incidence of ovarian cancer by age and menopausal status.
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
| Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608 |
| Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429 |
| Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451 |
| Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504 |
| Aboud, Katherine S; Barquero, Laura A; Cutting, Laurie E (2018) Prefrontal mediation of the reading network predicts intervention response in dyslexia. Cortex 101:96-106 |
| Kattan, Meyer; Bacharier, Leonard B; O'Connor, George T et al. (2018) Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy. J Allergy Clin Immunol Pract 6:1596-1603.e6 |
| Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521 |
Showing the most recent 10 out of 1014 publications
