This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Certain psychological factors, including depression, are risk factors for the development of diabetes and cardiovascular disease but the mechanism remains unclear. Neuroendocrine changes induced by these psychological factors, specifically activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS), might provide a unifying explanation. One limitation to assessing HPA axis activity in large population-based epidemiological studies as a risk factor for diabetes and cardiovascular disease has been the lack of a reliable, easy measurement to assess its function. The gold standard, a 24-hour urine collection for free cortisol, is cumbersome to perform in large-scale studies and is subject to variability. We hypothesize that salivary cortisol and adrenal volume are tightly correlated with HPA axis activity (as measured by 24-hour urine free cortisol) and therefore represent feasible approaches for assessment of HPA axis activity in large-scale cohort and epidemiological studies.
The aims of this study are to 1) enroll 50 African-American women ages 18 to 45 years into an overnight GCRC study; 2) obtain measures of psychological traits, anthropometry, and biochemical parameters; and 3) to conduct statistical analyses to determine the following correlations: (a) 24-hour urine free cortisol with total, 8am, and 11 pm salivary cortisol and with adrenal volume; (b) insulin sensitivity and body-mass index with 24-hour urine free cortisol, adrenal volume, and salivary cortisol; and (c) psychological factors with 24-hour urine free cortisol, adrenal volume, and salivary cortisol. Identifying reliable, efficient measures of HPA axis activity will allow them to be incorporated into large, prospective cohort studies of cardiovascular disease and diabetes to determine if HPA axis hyperactivity is a risk factor for these two important diseases, which are significant public health burdens.
| Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521 |
| Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168 |
| Robert Braši?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: |
| Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866 |
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
| Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72 |
| Al-Sofiani, Mohammed E; Yanek, Lisa R; Faraday, Nauder et al. (2018) Diabetes and Platelet Response to Low-Dose Aspirin. J Clin Endocrinol Metab 103:4599-4608 |
| Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429 |
| Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451 |
Showing the most recent 10 out of 1014 publications
