This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Background: Fatigue in survivors of cancer therapy interferes with quality of life, but the pathogenesis of the fatigue and its effective treatment remain poorly understood. We hypothesize that limitations in the movement of nerves and the surrounding soft tissues and joints contribute to fatigue in survivors of cancer. In those with chronic fatigue syndrome, chronic fatigue following service in the Persian Gulf War, and in limited numbers of cancer survivors, we have observed an increased prevalence of movement restrictions. Manual physical therapy techniques have been associated with improvements in fatigue, daily function, and objective examination findings in individuals with chronic fatigue. Orthostatic intolerance has been described with chronic fatigue syndrome patients and in cancer survivors. The former also show abnormalities of neuroendocrine hormones.
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