This is a cross-sectional study aimed to determine if postmenopausal women with abdominal adiposity or upper body fat phenotype have a hormonal profile that is associated with increased risk of breast cancer compared to women with femoral adiposity or lower body fat phenotype. Women who are eligible for the study will be asked to have their blood drawn on two consecutive mornings, and have their body fat distribution and percent body fat determined using various techniques. Serum levels of total estrone, estrone sulfate, estradiol, free estradiol, androstenedione, testosterone, free testosterone, luteinizing hormone, and follicular stimulating hormone, as well as sex hormone binding globulin, will be measured at Dr. Christopher Longcope's laboratory at the University of Massachussetts Medical Center in Woscester. We will use multiple regression analyses to answer our research question.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000054-39
Application #
6412819
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1991-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
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