The congenital long QT syndrome (LQTS) is a hereditary cardiac disorder that causes syncope, seizures, and sudden death from ventricular arrhythmia. At least four ion channel genes have been implicated in LQTS. We have located over 30 families in the Midwest where at least one family member has been clinically identified as having LQTS.
Our specific aims are to isolate DNA from patients and immediate family members and: 1. Screen the four ion channel genes to identify mutations which cause LQTS; 2. Prepare selected mutations for expression in systems to identify alterations in channel gating or protein; 3. Identify asymptomatic """"""""carriers"""""""" at risk for developing LQTS.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000055-39
Application #
6411855
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1978-12-01
Project End
2001-02-28
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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