EXCEED THE SPACE PROVIDED. The mission of the combined adult and pediatric General Clinical Research Center (GCRC) at the University of Chicago is to provide the resources, infrastructure and training for faculty to conduct outstanding translational research which will cure diseases and maintain the health of all people. The GCRC aims to create an environment in which this research is conducted in a safe and ethically sound manner. It is our aim to promote the optimal collaboration among basic researchers and clinical scientists to translate the findings at the bench to improved health at the bedside. Our areas of concentration include: (1) the understanding for the molecular basis for asthma, inflammatory bowel disease, cardiomyopathy,polycystic ovary syndrome, metabolic bone disease and new thyroid diseases; (2) the Diagnosis, Prevention and Treatment of Diabetes Mellitus and other Metabolic Syndromes; (3) Treatment and Diagnosis of Substance Abuse and Stress and (4) Physiology and pathology of sleep as it relates to obesity, ageing, pregnancy and other conditions. Additional areas of concentration include novel treatments for recurrent pregnancy loss; treatment of lung disease and septic shock. We submit 60 protocols from 34 different investigators (20 of whom have NIH funding) from 8 different specialties. We are requesting support for a Sleep and Chronobiology Core that would support 15 protocols. Without GCRC support these protocols cannot be performed. The request includes a core manager and a 0.5 FTE sleep technician as well as equipment necessary to conduct the studies. We are also requesting continued support for the Biostatistician and Statistical Geneticist to review all protocols. The University purchased for the GCRC an automated DNA extractor to keep pace with the large scale genotyping requested by our investigators. We are requesting continued support for laboratory personnel to meet this demand. We anticipate developing a curriculum with the NIH and the World Health Organization to train scientists from other countries in the area of clinical research. Together these requests will allow the GCRC to fulfill its mission of providing the very best in outstanding translational research for the public good.
| Rosenfield, Robert L; Ehrmann, David A (2016) The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr Rev 37:467-520 |
| Garyu, Justin W; Meffre, Eric; Cotsapas, Chris et al. (2016) Progress and challenges for treating Type 1 diabetes. J Autoimmun 71:1-9 |
| Rosenfield, Robert L (2015) The Polycystic Ovary Morphology-Polycystic Ovary Syndrome Spectrum. J Pediatr Adolesc Gynecol 28:412-9 |
| Maitland, Michael L; Xu, Chun-Fang; Cheng, Yu-Ching et al. (2015) Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib. Clin Cancer Res 21:365-72 |
| Bershad, Anya K; Jaffe, Jerome H; Childs, Emma et al. (2015) Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans. Psychoneuroendocrinology 52:281-8 |
| Fleming, Gini F; Schumm, Philip; Friberg, Greg et al. (2015) Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion. BMC Cancer 15:69 |
| Refetoff, Samuel; Bassett, J H Duncan; Beck-Peccoz, Paolo et al. (2014) Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. J Clin Endocrinol Metab 99:768-70 |
| Kirkpatrick, Matthew G; Francis, Sunday M; Lee, Royce et al. (2014) Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology 46:23-31 |
| Copinschi, Georges; Leproult, Rachel; Spiegel, Karine (2014) The important role of sleep in metabolism. Front Horm Res 42:59-72 |
| Müller, Peter; Quintana, Fernando A; Rosner, Gary L et al. (2014) Bayesian inference for longitudinal data with non-parametric treatment effects. Biostatistics 15:341-52 |
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