This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are virtually no readily available central 5-HT probes for research use in human subjects at the present time. These probes are needed if investigation into the role of central 5-HT system function is to continue in human subjects. If oral escitalopram challenge can be developed as an effective and safe probe of central 5-HT function, producing reliable physiological and behavioral effects in human subjects, this probe can then be used by clinical investigators in a wide variety of studies in which the responses of the central 5-HT system are investigated. Escitalopram is the purest SSRI formulation and is nearly devoid of receptor binding to any other relevant neurotransmitter receptor. Our objective is to determine the ability of three doeses of escitalopram .250 mg/kg, (e.g., 20 mg for and 80 kg male); .375 mg/kg (e.g., 30 mg for an 80 kg male); and .500 mg/kg, (e.g., 40 mg for an 80 kg male) to produce significantly robust physiological and behavioral responsed in healthy male human subjects and to determine the tolerability of each of these three doses of escitalopram given as a single, oral, pharmaco-challenge dose.
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| Rosenfield, Robert L (2015) The Polycystic Ovary Morphology-Polycystic Ovary Syndrome Spectrum. J Pediatr Adolesc Gynecol 28:412-9 |
| Maitland, Michael L; Xu, Chun-Fang; Cheng, Yu-Ching et al. (2015) Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib. Clin Cancer Res 21:365-72 |
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| Refetoff, Samuel; Bassett, J H Duncan; Beck-Peccoz, Paolo et al. (2014) Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. J Clin Endocrinol Metab 99:768-70 |
| Kirkpatrick, Matthew G; Francis, Sunday M; Lee, Royce et al. (2014) Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology 46:23-31 |
| Copinschi, Georges; Leproult, Rachel; Spiegel, Karine (2014) The important role of sleep in metabolism. Front Horm Res 42:59-72 |
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