This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The goal of this exploratory study is to examine the genetic basis of variations in acute responses to amphetamine. Variations have been observed in sensitivity and response to amphetamine, and there is evidence that these variations may be mediated by genetic variations in the neurotransmitter systems responsible for amphetamine's effects. We propose to compare the subjective and behavioral effects of d-amphetamine (10 mg or 20 mg) or placebo to genotypic variations in the dopamine, serotonin, and noradregenic neurotransmitter systems. We hypothesize that there will be a correlation between genotype and variations in acute responses to amphetamine.
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