This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Determination of the underlying etiology of hypercortisolism is extremely challenging due to the nonspecificity of available tests. Consequently, the treatment currently offered for this highly morbid condition is unsuccessful in 20-25% of subjects. We propose that analysis of the 24 hour secretory profile of salivary cortisol, serum cortisol, and plasma ACTH will provide sensitive markers for the correct diagnosis of the etiology of hypercortisolism. In addition, sleep-disordered breathing (SDB) is common in subjects with Cushing s syndrome. It is unclear whether the SDB results from the associated obesity or whether there is a direct effect of the glucocorticoids on sleep centers. We hypothesize that (1) the use of salivary cortisol 24 hour profile as well as salivary response to CRF stimulation with or without dexamethasone is an accurate method of diagnosing Cushing s syndrome and (2) the correction of the hypercortisolism will improve the SDB seen in Cushing s syndrome.
| Rosenfield, Robert L; Ehrmann, David A (2016) The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr Rev 37:467-520 |
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| Maitland, Michael L; Xu, Chun-Fang; Cheng, Yu-Ching et al. (2015) Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib. Clin Cancer Res 21:365-72 |
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| Refetoff, Samuel; Bassett, J H Duncan; Beck-Peccoz, Paolo et al. (2014) Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. J Clin Endocrinol Metab 99:768-70 |
| Kirkpatrick, Matthew G; Francis, Sunday M; Lee, Royce et al. (2014) Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology 46:23-31 |
| Copinschi, Georges; Leproult, Rachel; Spiegel, Karine (2014) The important role of sleep in metabolism. Front Horm Res 42:59-72 |
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