This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Corticotropin releasing hormone is present in the body and brain. It is a stress hormone that is released in response to a stressful event. We think that it may play a role in disorders such as depression, and thus may be worth studying in order to develop future treatments of depression and other psychiatric disorders. The form of corticotropin releasing factor being used in this study is corticorelin. Corticorelin is made in a laboratory to be similar to the type of corticotropin releasing factor in sheep. It is FDA approved for testing how well the pituitary and adrenal glands work in the body, and is usually given through an intravenous line, or IV. In this study, we are not using it to test your pituitary or adrenal glands, and instead of giving it IV, we are giving in the form of a nasal sprayer. Therefore its use in this research study is considered experimental. We expect that the amount of drug your body absorbs intranasally to be much less than when the drug is given IV. This should decrease the risks of the drug.20 healthy volunteers and 20 non-depressed subjects with a history of depression will undergo a double-blind, placebo-crossover challenge with intranasal CRH on two non-consecutive study days.
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