This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Background & Rationale: Hereditary cancers, while rare, have a significant impact on affected families with approximately 50% of individuals within those families expected to develop cancer. Identification of at risk individuals and modification of risks by changes in lifestyle and diet and specific monitoring of these individuals may have a large impact on these families. Identification of at risk individuals by the further development of biomarkers and DNA analysis will further define the risks for each individual. In the absence of known DNA markers or known mutations, banking of DNA will enable samples to be available from these families that may help future generations to modify their cancer risks. This study helps us to establish a DNA and serum bank of samples in parallel with well characterized pedigrees in hereditary cancer families.
Study Aims : To develop pedigrees, establish lymphoblastoid cell lines and store blood samples (DNA, serum, cells) that can be used at a later date to perform genetic testing using markers for specific cancers as these markers are cloned. (e.g. BRCA1 and BRCA2 for breast cancer susceptibility).Study Population: This protocol does not have a defined accrual number. This study is a mechanism for collecting biological specimens to be used for other IRB-approved research studies. Design: High risk individuals seen as patients in the Cancer Risk Clinic are asked to donate a blood sample for research purposes

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000055-46
Application #
7604799
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-03-01
Project End
2007-09-16
Budget Start
2007-03-01
Budget End
2007-09-16
Support Year
46
Fiscal Year
2007
Total Cost
$14,880
Indirect Cost
Name
University of Chicago
Department
Pathology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
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