The objective of this study is to assess whether dehydroepiandrosterone (DHEA) administration influences the pharmacokinetics of triazolam. Triazolam pharmacokinetics will be assessed before and at 4x's during DHEA administration. 24 Elderly subjects will be used due to their inherently low endogenous concentrations of DHEA and DHEA-S which will be increased as a result of DHEA administration. The results of this study will provide information regarding the influence of fluctuations in DHEA concentrations on the pharmacokinetics of triazolam.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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