Patients with high-risk Stage III or IV metastatic melanoma will enter the study. The study will run after completion of the MF59 adjuvant peptide study. Patients randomized into 3 groups of 12 each. Each will be immunized intravenously with autologous DC (5-10 x 10 pulsed with one of the P1-P3 peptides (100ug) in 0.1 ml phosphate buffered saline, pH 7.4 once a week for four weeks. The plan is to do a Phase II study with the peptide identified as eliciting the predominant reactivity on subsequent testing and/or those found to elicit antitumor response.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
2000
Total Cost
$3,034
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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