The specific aims of this protocol are: 1)to assess the toxicities of and determine the maximum tolerated dose (MTD) of subcutaneous calcitriol given Day 1 - 3 in combination with carboplatin (ABC = 6) Day 3. 2)to assess the toxicities of and determine the maximum tolerated dose (MTD) of carboplatin Day 3 when given with subcutaneous calcitriol Day 1 - 3 at a dose one dosage level less than the MTD. 3)to determine the effect of administration of calcitriol on the AUC of carboplatin. 4)to assess the relationship between the ABC of carboplatin and the myelosuppression seen following the administration of carboplatin + calcitriol. 5)to evaluate the safety and efficacy of carboplatin + calcitriol in patients with malignant glioma. Additionally, this will allow us to gather important information regarding drug interactions.

Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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