This study will determine the effect of a single dose (12ug) of calcitroil on vitamin D-responsibe parameters (vitamin D receptor [VDR], fructose 1,6 biphosphatase [FBPase], cytidine deaminase [CDD] 24 hydroxylase [24OH ase]) in PBM (CLL & Monocytic cells) and the effect of dexamethasone 4mg QDx4 Wednesday, Thursday, Friday, Saturday, (WThFS) + calcitriol 12ug QD X 3, Wednesday, Thursday, Friday (WThF) on these parameters. We will also investigate the pharmacokinetics and pharmacodynamics of calcitriol. This trial will be conducted in a single patient who happens to have both stable asymptomatic CLL and AIPC.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000056-40
Application #
6459708
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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