This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that hepatitis C virus induces a specific cellular immune deficiency in which CD4 lymphocytes play a central role that precludes HCV clearance by induction of a mechanism that maintains adequate levels of virus-specific antibody but impairs cellular immune clearance. A cohort of hemophilic patients infected with HCV are followed over time; cellulor and humerol immune responses to HCV antigens are characterized and correlated with the extent of liver disease and response to therapy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000058-45
Application #
7375052
Study Section
Special Emphasis Panel (ZRR1-CR-2 (01))
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
45
Fiscal Year
2006
Total Cost
$37,965
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Eastman, Meridith L; Verhulst, Brad; Rappaport, Lance M et al. (2018) Age-Related Differences in the Structure of Genetic and Environmental Contributions to Types of Peer Victimization. Behav Genet 48:421-431
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