This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to develop a neuroanatomic brain map of cognitive functions in healthy adults and apply this knowledge to the study of patients with cognitive dysfunction (multiple sclerosis, Alzheimer's disease, stroke). To achieve this goal, we will perform task activation experiments involving five cognitive domains: (1) working memory, (2) explicit and implicit long-term memory, (3) selective, divided, and sustained attention, (4) complex motor processes, and (5) conceptual reasoning. The proposed work on healthy adults should yield important new information regarding functional anatomic relationships during cognitive activity. These studies will also provide essential information needed to achieve our broad, long-term objective: to develop a comprehensive functional brain imaging approach to the study of neurological disorders that produce cognitive impairment.
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