In this study the investigators will evaluate the relationship of a metabolic probe for cytochrome P450 3A activity to cyclosporine (CSA) pharmacokinetics. They will also evaluate the ratio of intestinal and hepatic CYP3A activity and will study the effect of grapefruit juice on CSA bioavailability using a new microemulsion formulation of cyclosporine in healthy volunteers.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Rao, Satish S C; Valestin, Jessica A; Xiang, Xuelian et al. (2018) Home-based versus office-based biofeedback therapy for constipation with dyssynergic defecation: a randomised controlled trial. Lancet Gastroenterol Hepatol 3:768-777
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Lorenz, Douglas J; Levy, Steven; Datta, Somnath (2018) Inferring marginal association with paired and unpaired clustered data. Stat Methods Med Res 27:1806-1817
Oweis, Reem Reda; Levy, Steven M; Eichenberger-Gilmore, Julie M et al. (2018) Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study. Community Dent Oral Epidemiol 46:527-534
Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
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Spracklen, Cassandra N; Ryckman, Kelli K; Robinson, Jennifer G et al. (2017) Low Birth Weight and Risk of Later-Life Physical Disability in Women. J Gerontol A Biol Sci Med Sci 72:543-547
Reber, Justin; Tranel, Daniel (2017) Sex differences in the functional lateralization of emotion and decision making in the human brain. J Neurosci Res 95:270-278

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