This study will evaluate how uncoated asbestos fibers activate normal alveolar macrophages, evaluate mechanisms that might explain the release of cytokines by alveolar macrophages in patients with asbestosis, determine if the p42/p44 kinase and p38 kinase pathways are activated by uncoated or coated asbestos fibers in alveolar macrophages and monocytes, and determine if uncoated or coated asbestos triggers activation of NFkB-alpha transcription factor necessary for cytokine gene expression.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
38
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Rao, Satish S C; Valestin, Jessica A; Xiang, Xuelian et al. (2018) Home-based versus office-based biofeedback therapy for constipation with dyssynergic defecation: a randomised controlled trial. Lancet Gastroenterol Hepatol 3:768-777
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