This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Bleaching or tooth whitening continues to grow in popularity as an effective non-invasive method to alter the shade of teeth discolored by either intrinsic or extrinsic stains. Bleaching with a custom tray is by far the most widely recommended method of tooth whitening by dentists. Tooth sensitivity is a common unpleasant side effect of external tooth bleaching. MI paste has recently been approved by the American Dental Association for the treatment of hypersensitivity. The active ingredient in MI paste is a milk derived product, casein phospho-peptide-amorphous calcium phosphate that reduces sensitivity by precipitation of calcium phosphate compound onto the exposed dentin surface leading to occlusion of dentin tubules. The use of MI paste has also been advocated to reduce the sensitivity associated with bleaching. However, the available data are based on case reports and no well controlled clinical trials have investigated the effect of MI paste in patients undergoing bleaching. The purpose of this study is to evaluate the effectiveness of MI paste in reducing sensitivity associated with night guard vital bleaching in patients with or without a history of hypersensitivity.
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