This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
Specific Aim #1 : Demonstrate that a chronic, high-force eccentric intervention will greatly improve muscle size and strength. The following hypotheses will be tested: 1. Following 12 weeks of a high-force eccentric intervention there will be a significant increase in muscle fiber size of the vastus lateralis as measured by muscle biopsy. 2. Following 12 weeks of a high-force eccentric intervention there will be a significant increase in the isometric strength of the quadriceps muscles as measured by dynamometry.
Specific Aim #2 : Demonstrate that a chronic, high-force eccentric intervention will improve insulin sensitivity in post-menopausal females with impaired glucose tolerance. The following hypotheses will be tested: 3. Following 12 weeks of a high-force eccentric intervention there will be a significant increase in insulin sensitivity as measured by hyperinsulinemic-euglycemic clamp.
Specific Aim #3 : Demonstrate that a chronic, high-force eccentric intervention will improve functional performance in post-menopausal females with impaired glucose tolerance. The following hypotheses will be tested: 4. Following 12 weeks of a high-force eccentric intervention there will be a significant improvement in function as measured by timed stair ascent/descent, six-minute walk, and step up and over tests.
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