This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Three important hypotheses will be tested related to gastric bypass surgery for the treatment of severe obesity: 1) Roux-en-Y gastric surgery is an effective and safe procedure to reduce weight as shown by lower long-term total and disease specific mortality rates compared to severely obese patients who have not had gastric surgery for treatment of obesity; 2) Roux-en-Y surgery significantly lowers long-term morbidity compared to matched severely obese patients who have not had surgery; 3) Significant weight loss after Roux-en-Y surgery will be maintained over a three year follow-up period.
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