Failure of the hypothalamic-pituitary-testicular (HPT) axis during aging may play an important role in age-associated disability. This study will investigate the mechanisms by which aging modifies activity of the(HPT) axis, dissecting the specific impact of aging on hypothalamic secretion of GnRH, pituitary secretion of LH, and testicular secretion of testosterone.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
36
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Holkova, Beata; Yazbeck, Victor; Kmieciak, Maciej et al. (2017) A phase 1 study of bortezomib and romidepsin in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma, indolent B-cell lymphoma, peripheral T-cell lymphoma, or cutaneous T-cell lymphoma. Leuk Lymphoma 58:1349-1357
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