This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with chronic kidney disease (CKD) are at increased risk of atherosclerotic cardiovascular disease. In fact, cardiovascular disease accounts for approximately 50% of the mortality seen in patients with End Stage Renal Disease. These patients are thirty times more likely to die from cardiovascular disease and its complications than the general population. It is believed that treatment with calcium containing phosphate binders leads to the progression of coronary artery and aortic calcification. Two groups of patients with chronic kidney disease will be enrolled into the proposed study. One group of patients will have Stage IV chronic kidney disease (creatinine clearance between 15 to 30 mL/min) and the second group will have end-stage renal disease currently stable on hemodialysis. In each of the two groups, half will have diabetes mellitus. The purpose of this study is to test whether preparations of Vitamin D replacement contribute to the heart disease seen commonly in patients with chronic kidney disease.
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