This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Traumatic brain injury (TBI) is an increasing area of public health concern. More than 2 million individuals sustain TBI each year. Disorders arising from TBI are more common than any other neurological disease except headache. Interventions to reduce the morbidity and mortality associated with TBI are urgently needed. This study will attempt to address these issues by exploring the following hypothesis: Can selegiline enhance recovery of cognitive functioning in individuals who recently sustained mild TBI?Subjects will include individuals with mild TBI admitted and discharged from the inpatient wards of the VCU Medical Center. This program of research will examine the effectiveness of selegiline in a limited randomized, double-blind, placebo-controlled trial. Results from this study will be used to determine if larger trials of this intervention are warranted. The primary outcome measures for documenting recovery will be improvement in neuropsychological test scores.
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