Abstract

The purpose is to determine whether in vitro measurements of lipoprotein lipase (LpL) activity will give us a handle on the in vivo processing of chylomicrons and to determine what levels of remnants would be observed in both heterozygotes and probands. We hope to evaluate patients with lipid abnormalities that correspond to those observed in heterozygotes for LpL deficiency as this would suggest that certain lipoprotein changes in more general populations correlate with changes in LpL activity and/or the LpL gene.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000068-27S1
Application #
3884212
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Feghali, Maisa; Khoury, Jane C; Shveiky, David et al. (2012) Association of vaginal delivery efforts with retinal disease in women with type I diabetes. J Matern Fetal Neonatal Med 25:27-31
Mimouni, F; Mughal, Z; Tsang, R C et al. (1995) Effect of maternal oxygen therapy on placental calcium transport in intrauterine growth retarded rats. J Am Coll Nutr 14:165-8
Samaratunga, R C; Thomas, S R; Hinnefeld, J D et al. (1995) A Monte Carlo simulation model for radiation dose to metastatic skeletal tumor from rhenium-186(Sn)-HEDP. J Nucl Med 36:336-50
Nordlund, J J; Csato, M; Babcock, G et al. (1995) Low ICAM-1 expression in the epidermis of depigmenting C57BL/6J-mivit/mivit mice: a possible cause of muted contact sensitization. Exp Dermatol 4:20-9
Green, D W; Mimouni, F; Khoury, J (1995) Decreased platelet counts in infants of diabetic mothers. Am J Perinatol 12:102-5
Luggen, M; Belhorn, L; Evans, T et al. (1995) The evolution of Raynaud's phenomenon: a longterm prospective study. J Rheumatol 22:2226-32
Cruz, M L; Wong, W W; Mimouni, F et al. (1994) Effects of infant nutrition on cholesterol synthesis rates. Pediatr Res 35:135-40
Cruz, M L; Bhadra, S; Subbiah, M T et al. (1994) Serum lipid peroxidation potential in infants. Arch Pediatr Adolesc Med 148:1212-5
Mimouni, F; Campaigne, B; Neylan, M et al. (1993) Bone mineralization in the first year of life in infants fed human milk, cow-milk formula, or soy-based formula. J Pediatr 122:348-54
Thomas, T J; Seibold, J R; Adams, L E et al. (1993) Hydralazine induces Z-DNA conformation in a polynucleotide and elicits anti(Z-DNA) antibodies in treated patients. Biochem J 294 ( Pt 2):419-25

Showing the most recent 10 out of 231 publications