Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may due largely in part to a lack of understanding of its pathogenesis. The primary objective of the study was to evaluate the microbiology (through bacteriologic and viral cultures) and local histologic (through maxillary sinus mucosal biopsies) and immunologic (through assays of inflammatory mediators of the maxillary sinus washes) responses in children with chronic sinusitis. The secondary objective was to refine our research methodologies during the course of the study in preparation for a large-scale investigation.

Project Start
1999-12-01
Project End
2001-02-28
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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