This study is designed to validate the reliability and reproductibility of nasal potential difference measurements in patients with cystic fibrosis (CF) and normal individuals prior to applying this technique as an outcome measurement in clinical trials. This procedure measures the electrical voltage at the surface of epithelial cells lining the inferior turbinate (inside the nose) and their response to certain chemical stimuli. These small voltages reflect sodium and chloride transport and are characteristically different in CF patients compared to normal individuals. It is postulated that such measurements will be useful in demonstrating the efficacy of pharmacological agents directed at normalizing electrolyte transport in airway epithelial cells.

Project Start
1999-12-01
Project End
2001-02-28
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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