This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Infantile reflux is common. The gold standard for the diagnosis of infantile gastroesophageal reflux (GER) has been intraesophageal pH monitoring. Intraluminal impedance monitoring is a new technique which measures fluid bolus movement independent of pH and offers an alternative mechanism to study GER. Evaluation of adults with GER utilizing combined multichannel intraluminal impedance (MII)/pH testing shows that acid and nonacid reflux events occur with equal frequency, 55% vs. 45% (1.2 to 1) compared with 15% vs. 85% (1 to 5.6) seen in the first studies in infants. Comparison of MII and pH probe monitoring demonstrated MII to be superior in the detection of reflux events, 96% vs. 28% respectively. Therefore, continuous impedance monitoring (6 hours) will better characterize infantile GER.
Aim :
The aim of this study is to redefine infantile GER in terms of acid and nonacid reflux episodes. Methods: Fifty infants, ages two weeks to one year, with symptomatic GER referred to the pediatric gastroenterology department will be enrolled in this study. The subjects will be admitted for a 20-hour continuous study undergoing simultaneous pH and multichannel intraluminal impedance (MII) testing. Evaluation: Tracings will be evaluated to identify the frequency and duration of both acid and nonacid reflux events during the pre-and-postprandial periods as well as during sleep.
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