This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with cystic fibrosis are frequently admitted to the hospital for the treatment of lung infections due to Pseudomonas aerginosa. They are typically treated with an aminoglycoside and an anti-pseudomonal beta lactam antibiotic. Serum concentrations are monitored to assure therapeutic levels and to prevent adverse effects. There are two dosing regimens that are used, every 8 hour (conventional) and every 24 hour (once daily). There is not a consensus in the literature for superiority of one regimen over the other; therefore, it is beneficial to compare the two regimens within the same patient.
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