This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P1055 is a multicenter, non-treatment, observational study designed to better understand the impact of HIV on the development of psychiatric symptomatology in a cohort of perinatally HIV-infected children and adolescents, when compared to a cohort of demographically matched control subjects. The significance of this study rests in its focus on a potentially high-risk sample exposed to a neurotropic virus and therapeutic regimens with altered penetration into the brain. For the purposes of this study, subjects in the control group will be frequency matched (i.e., will be matched with the same percentage of 6 to < 12 year-old females, 6 to < 12 year-old males, > 12 to < 18 year-old females, and > 12 to < 18 year-old males) to those in the HIV-infected group by gender and age strata. Subjects will not receive treatment in this study; subjects and their parents/primary caregivers will respond to a series of questionnaires/measures which will be used to assess the prevalence and severity of current psychiatric symptoms and disorders and to assess changes over time. The study is divided into two components, the prevalence and severity of current psychiatric disorders and symptoms (Mental Health Component at the first study visit) and changes in symptomatology over time (Follow-Up Component at the second and third study visits). In addition, a subset of perinatally HIV-infected and control subjects (100-120 subjects from each group) and their parents/primary caregivers will receive additional measures, in the form of semi-structured psychiatric interviews, to further identify the differential frequency of psychiatric symptoms in HIV-infected children or adolescents and control subjects and to establish the feasibility of a long-term follow-up study.
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