This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The prevalence of type 2 diabetes among children and adolescents is a growing problem (1) and is related to the increasing incidence of obesity and sedentary lifestyle in this age group. The primary task of the management of type 2 diabetes is to maintain a level of blood glucose that closely approximates normal levels. Acceptable management of the disease involves a complex balance of medication, diet and exercise and adherence to the recommended regimen is key to successful self-care. In children and adolescents specifically, management is a family affair, requiring some degree of parental monitoring and the opportunity for parent and child to interface around a stressful aspect of the child's life. For the child with type 2 diabetes, management adds another life context where issues related to independence and negotiation between parent and child are highlighted. The proposed study aims to provide longitudinal data regarding the relation between tasks of illness management and those normative tasks of the day-to-day life of an adolescent in a sample of adolescents with type 2 diabetes. We will examine two salient aspects of adolescents' lives, behavioral autonomy and the quality of the relationship between parent and child, within the two contexts of their lives, diabetes-related and normative. The relationships between these factors and diabetes-related outcomes including adherence to treatment regimen will be assessed.
Specific aims are: 1. To evaluate how behavioral autonomy (level of independent management or self-governance) and parent-child conflict relate to adherence to the type 2 diabetes treatment regimen. In this prospective study, do autonomy and/or conflict predict regimen adherence? 2. To evaluate the relationship of behavioral autonomy regarding normative tasks, (e.g., chores, schoolwork) to behavioral autonomy regarding type 2 diabetes management tasks (diet, exercise, blood glucose testing). 3. To evaluate the relationship of the quality of parent-adolescent negotiation about normative issues to the quality of parent-child negotiation about type 2 diabetes management tasks.Data will be collected from approximately 170 parent-adolescent dyads over a 1 year period from 8 sites that are participating in the TODAY trial, enrolling youth of differing ethnicities. Self-report measures of behavioral autonomy and parent-child conflict will be collected at baseline, 6 months and 12 months. ANOVA will be used to assess whether these scores predict adherence at follow-up, controlling for demographic factors such as age. Changes over time will also be examined. The results will help to inform the future development of appropriate interventions to improve regimen adherence, promote successful weight loss and decrease relational conflict in youth with type 2 diabetes and might include helping parents to develop more realistic expectations of their child regarding diabetes self-care.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000069-45
Application #
7605109
Study Section
Special Emphasis Panel (ZRR1-CR-9 (01))
Project Start
2007-03-01
Project End
2008-02-29
Budget Start
2007-03-01
Budget End
2008-02-29
Support Year
45
Fiscal Year
2007
Total Cost
$1,109
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Berkowitz, Robert I; Marcus, Marsha D; Anderson, Barbara J et al. (2018) Adherence to a lifestyle program for youth with type 2 diabetes and its association with treatment outcome in the TODAY clinical trial. Pediatr Diabetes 19:191-198
Arslanian, Silva; El Ghormli, Laure; Kim, Joon Young et al. (2018) The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in ?-Cell Function in TODAY. Diabetes Care :
Kriska, Andrea; El Ghormli, Laure; Copeland, Kenneth C et al. (2018) Impact of lifestyle behavior change on glycemic control in youth with type 2 diabetes. Pediatr Diabetes 19:36-44
Venditti, E M; Tan, K; Chang, N et al. (2018) Barriers and strategies for oral medication adherence among children and adolescents with Type 2 diabetes. Diabetes Res Clin Pract 139:24-31
Gidding, Samuel S; Bacha, Fida; Bjornstad, Petter et al. (2018) Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study. J Pediatr 192:86-92.e5
Jacobson, Denise L; Lindsey, Jane C; Coull, Brent A et al. (2018) The Association of Fat and Lean Tissue With Whole Body and Spine Bone Mineral Density Is Modified by HIV Status and Sex in Children and Youth. Pediatr Infect Dis J 37:71-77
Young, Kendra A; Maturu, Amita; Lorenzo, Carlos et al. (2018) The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, ?-cell function, and diabetes in Hispanics and African Americans. J Diabetes Complications :
Kelsey, Megan M; Braffett, Barbara H; Geffner, Mitchell E et al. (2018) Menstrual Dysfunction in Girls From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. J Clin Endocrinol Metab 103:2309-2318
Kleinberger, Jeffrey W; Copeland, Kenneth C; Gandica, Rachelle G et al. (2018) Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial. Genet Med 20:583-590
Levenson, Amy E; Wadwa, R Paul; Shah, Amy S et al. (2017) PCSK9 Is Increased in Youth With Type 1 Diabetes. Diabetes Care 40:e85-e87

Showing the most recent 10 out of 837 publications