This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to evaluate if pre-treatment with hydrocortisone speeds the onset of response to Venlafaxine extended release (XR). In addition, we will evaluate if hydrocortisone pre-treatment augments Venlafaxine XR response. Patients will be treated with Venlafaxine for 6 weeks. Eligible patients will be admitted to the GCRC for 2 days, where they will be randomly assigned to receive either hydrocortisone or placebo intravenously during their stay in the hospital. Mood assessments, as well as neuropsychological tests of memory, will be completed at most visits.
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