This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Whole organ pancreas transplantation has traditionally been considered only for type 1 diabetics, usually those with the diabetic complication of renal failure, so that these patients received combined cadaveric kidney-pancreas transplants (KPTx) or a pancreas transplant after a previous living or cadaveric donor kidney transplant (PAK). Patients with type 2 diabetics displaying characteristics of the combined (insufficient/resistant) diabetic phenotype will be offered pancreas transplantation and studied with regard to (1) their pretransplant insulin secretory state and (2) parmeters of insulin sensitivty.
The specific aim of this project is to establish metabolic characteristics of patients successfully treated with combined transplantation as defined by a decline of insulin requirements to zero.
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