This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Food allergy is becoming a major health problem in the United States, affecting about 2.5% of the population, or 6.5 million Americans. Peanut and tree nut allergies affect about 1.1% of the population1 and fish and shellfish affect approximately 0.5% - 0.7%. Other foods, such as kiwi and various seeds [e.g. sesame, mustard, poppy, etc.] appear to be an increasing problem. Although milk, eggs and peanuts account for over 80% of food hypersensitivity reactions in children,2 hypersensitivity reactions to peanuts, tree nuts, seeds and seafood tend to be more severe in nature, sometimes resulting in death,3;4 and generally are lifelong.5 Despite the prevalence of these food hypersensitivities and the number of serious anaphylactic reactions each year, the identification of clinically relevant allergens is incomplete and our understanding of the immunobiology of peanut, tree nut, seed and seafood hypersensitivity is very limited.6-9 The overall goal of this project is to characterize food allergens responsible for clinical reactivity to a variety of foods and to isolate DNA encoding these proteins. A bank of food allergen DNA will enable us to take advantage of any of a number of novel strategies under investigation for modulating the allergic response in food allergic patients

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000071-45
Application #
7718113
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-03-01
Project End
2009-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
45
Fiscal Year
2008
Total Cost
$2,854
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Coplan, Jeremy D; Webler, Ryan; Gopinath, Srinath et al. (2018) Neurobiology of the dorsolateral prefrontal cortex in GAD: Aberrant neurometabolic correlation to hippocampus and relationship to anxiety sensitivity and IQ. J Affect Disord 229:1-13
Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866
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Chen, Teresa K; Appel, Lawrence J; Grams, Morgan E et al. (2017) APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension). Arterioscler Thromb Vasc Biol 37:1765-1769
Ku, Elaine; Gassman, Jennifer; Appel, Lawrence J et al. (2017) BP Control and Long-Term Risk of ESRD and Mortality. J Am Soc Nephrol 28:671-677
Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Gern, James E; Calatroni, Agustin; Jaffee, Katy F et al. (2017) Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy. J Allergy Clin Immunol 140:836-844.e7
Abdallah, Chadi G; Jackowski, Andrea; Salas, Ramiro et al. (2017) The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder. Neuropsychopharmacology 42:1739-1746

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