EXCEED THE SPACEPROVIDED. The General Clinical Research Center (GCRC) serves as the physical and intellectual focus for clinicalresearch endeavors at the Mount Sinai School of Medicine. For 42 years, the GCRC has provided theessential resources to: 1) elucidate pathophysiologic mechanisms responsible for a variety of diseases, and2) facilitate the rapid translation of advances in basic scientific knowledge into new or improved methods forpatient care. The GCRC also serves as the primary training site for clinical investigators in thePhysician/Scientist tradition. Continuation of this invaluable research and training resource will permit theaccomplishment of on-going studies by multidisciplinary teams of investigators. This application provides highlights of the clinical research that has been conducted since the previousgrant submission in 2000 and presents the proposed research activities for the upcoming five-year cycle.GCRC research activities will continue to emphasize translational research, especially in the development ofmolecular-based diagnostic, preventive and therapeutic modalities. Areas of focus will includeneuropsychiatric, inherited metabolic and allergic disorders, epidemiology of cancer, HIV, gene therapy andenvironmental determinants of development. GCRC educational activities will continue to integrate with new,evolving Institutional programs for education and training of clinical investigators. The Imaging Core willexpand to include PET scanning and the provision of more interpretative services. The Informatics Core willprovide a new software platform to facilitate protocol management and integration with other Institutionaldatabases. The Core Laboratory will further expand its molecular biology services including the developmentof a new, GCRC-based Proteomics Core, which will provide expertise and instrumentation to investigatorsseeking new biomarkers of disease. These new technologies should position the GCRC to take advantage ofanticipated medical advances resulting from the molecular and technological revolutions.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000071-46
Application #
7608736
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Merchant, Carol
Project Start
1975-10-01
Project End
2009-07-31
Budget Start
2009-03-01
Budget End
2009-07-31
Support Year
46
Fiscal Year
2009
Total Cost
$1,482,405
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451
Kattan, Meyer; Bacharier, Leonard B; O'Connor, George T et al. (2018) Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy. J Allergy Clin Immunol Pract 6:1596-1603.e6
Coplan, Jeremy D; Webler, Ryan; Gopinath, Srinath et al. (2018) Neurobiology of the dorsolateral prefrontal cortex in GAD: Aberrant neurometabolic correlation to hippocampus and relationship to anxiety sensitivity and IQ. J Affect Disord 229:1-13
Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866
Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671
Sheffield, Perry E; Uijttewaal, Simone A M; Stewart, James et al. (2017) Climate Change and Schools: Environmental Hazards and Resiliency. Int J Environ Res Public Health 14:
Juraschek, Stephen P; Appel, Lawrence J; Miller 3rd, Edgar R (2017) Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension. Am J Hypertens 30:871-875
Chen, Teresa K; Tin, Adrienne; Peralta, Carmen A et al. (2017) APOL1 Risk Variants, Incident Proteinuria, and Subsequent eGFR Decline in Blacks with Hypertension-Attributed CKD. Clin J Am Soc Nephrol 12:1771-1777
Ramratnam, Sima K; Visness, Cynthia M; Jaffee, Katy F et al. (2017) Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families. Am J Respir Crit Care Med 195:674-681
Chen, Teresa K; Appel, Lawrence J; Grams, Morgan E et al. (2017) APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension). Arterioscler Thromb Vasc Biol 37:1765-1769

Showing the most recent 10 out of 869 publications