The hypothesis of this study is that standard methods of skin preparation prior to application of EMLA cream will affect the absorption of its active components and impact its effectiveness. This open label study will evaluate the effectiveness and safety of EMLA on skin prepared by chemical and mechanical methods. Relief of pain associated with venipuncture will be assessed. A pharmacokinetic evaluation of the absorption of lidocaine and prilocaine will also be made. The significance of this study is that EMLA cream is a widely used topical analgesic but has not been evaluated under conditions that may disrupt the stratum corneum barrier. Therefore, the effect of four commonly used skin preparation procedures on the effectiveness of EMLA cream has significance for the routine use of this product.

Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
37
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
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