This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
The aim of the CHARTER Program is to examine the evolving nature of neuroAIDS, particularly with modern HIV medication use. The study was designed as a 5-year program (2002-2007) with a 3-year extension (2007-2010). This three year period was seen as an opportunity to gather additional data. The Investigators are interested in learning more about HIV-associated neurological disease and will collect detailed medical, laboratory, psychological and psychiatric histories and evaluations over the next 3 years on approximately 300 people, every six months at the 6 sites. This information will help them understand if and how anti-retroviral medications (HAART) affect the complication or prevention of neurological disease and impairment (such as dementia or peripheral neuropathy) in those infected with HIV. Researchers are also interested in the effect HAART has on the metabolic changes that often occur, i.e., loss of or redistribution of body fat. A secondary concern is how HAART and psychiatric medications interact. Study participants will be asked to undergo testing every 6 months. Basic testing will include neurological examination, neuropsychological evaluation, psychiatric history, blood collection, and a lumbar puncture. Additional testing may include nerve conduction studies, quantitative sensory testing, MRI, and or skin biopsy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000073-46
Application #
7952146
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2009-04-01
Project End
2009-07-31
Budget Start
2009-04-01
Budget End
2009-07-31
Support Year
46
Fiscal Year
2009
Total Cost
$54,900
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
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