Abstract

Autistic Disorder (AD) is a pervasive developmental disorder which is typically diagnosed during childhood. Children with AD often have problematic behaviors which can make them extremely difficult to manage by caretakers, teachers, and therapists. Pharmacologic interventions directed at reducing dysfunctional behaviors in youngsters with AD have primarily included dopamine-blocking antipsychotic agents and serotonergic re-uptake inhibitors. The purpose of this study is to examine whether the atypical antipsychotic agent risperidone may be successful in ameliorating dysfunctional behaviors in children with AD. We hypothesize that because risperidone effects both serotonergic and dopaminergic neural transmission, that this medication will be effective in treating youngsters with AD. All patients who have enrolled in this study have had a significantly positive therapeutic response to risperidone. Due to the small sample size, no results of any statistical analyses are yet available.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000080-34
Application #
5219160
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
34
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671
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Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Gibson, Kelly S; Stark, Sydney; Kumar, Deepak et al. (2017) The relationship between gestational age and the severity of neonatal abstinence syndrome. Addiction 112:711-716

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