Vasopressin (AVP) is a peptide hormone actively involved in the regulatin of body fluid osmolality, blood volume, blood pressure, and cell prliferation via the stimulation of specific membrane-bound receptors classified into pituitary subtypes having distinct pharmacological profiles and intracellular second messengers. The secretion of AVP is an absolute requirement for the maintenacne of fluid homeostasis. An agent that increases urine output by producing a free water diuresis would be a significant advantage in conditions such as hyponatremia of congestive heart failure, liver chirrhosis, nephrotic syndrome and the syndrome of inappropriate secretin of antidiuretic hormone (SIADH). This study is designed to evaluate the effecacy, safety, and tolerance of VPA-985, a selective non-peptidic orally active AVP antagonist, in patients with hyponatremia due to drug induced SIADH. Preliminary pharmacokinetic and pharmacodynamic parameters will be asessed.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
36
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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