Developing strategies for recognizing and treating children with Sleep Disordered Breathing (SDB) is not possible in the absence of essential epidemiological data that address the distribution of measures of SDB in pediatric populations. The potential public health importance of this is underscored by preliminary data that suggest that risk of SDB is increased in susceptible populations, in particular, in African Americans and in children born prematurely. The goals of this study are to collect fundamental data regarding the distribution of measures of SDB in a pediatric population, prevalence of clinically significant SDB in children risk factors, and associated co-morbidity. In this cohort study with a nested case control arm, we will exploit access to a well-characterized cohort of 8 to 10 year olds (50% born prematurely) who have participated in longitudinal studies of behavior and cognition. The cohort consists of a birth cohort (1988-1993). SDB will be evaluated in 850 children with in-home state-of the art monitoring techniques, measuring abdominal and thoracic movement, oxygen saturation, movement, body position, and ECG. A broad array of risk factors will be evaluated: sociodemographic characteristics; upper and lower airway size and function (questionnaire, spirometry, acoustic pharygometry and rhinometry); perinatal exposures (from neonatal records); family history; and home environment (passive smoking; sleep patterns, maternal-child stress indices). Behavior, cognitive skills, attention, and health-related quality of life will be assessed with standardized instruments to assess co-morbidities (potential SDB outcomes). A case-control arm will provide more detailed data for three groups of children: definite SDB by home assessment; equivocal SDB; and no SDB. In this arm, children will be studied with conventional overnight in-laboratory polysomnography (in the GCRC), daytime Multiple Sleep Latency Tests, and cephalometry. Its purposes are to confirm and extend the findings of the in-home assessments with comprehensive laboratory studies and objective measures of sleepiness. Collection of a comprehensive data set will help identify which measures best discriminate symptomatic (e.g., snoring, sleepy) from asymptomatic children. Comprehensive risk factor and outcome data should improve strategies for identifying and intervening in high risk children. Follow-up of a cohort with a large number of preterm children also affords an excellent opportunity to study SDB co-morbidities in a group at high risk for developmental delays (who may be susceptible to additive adverse effects of SDB) and to explore new hypotheses regarding the role of developmental factors in SDB.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000080-40
Application #
6566886
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Saade, G R; Thom, E A; Grobman, W A et al. (2018) Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound Obstet Gynecol 52:757-762
Inker, Lesley A; Grams, Morgan E; Levey, Andrew S et al. (2018) Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium. Am J Kidney Dis :
Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671
Bustos, Martha L; Caritis, Steve N; Jablonski, Kathleen A et al. (2017) The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth. Am J Obstet Gynecol 217:369.e1-369.e9
Chen, Teresa K; Appel, Lawrence J; Grams, Morgan E et al. (2017) APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension). Arterioscler Thromb Vasc Biol 37:1765-1769
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Gibson, Kelly S; Stark, Sydney; Kumar, Deepak et al. (2017) The relationship between gestational age and the severity of neonatal abstinence syndrome. Addiction 112:711-716

Showing the most recent 10 out of 753 publications