This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a Phase I study to evaluate the feasibility of electrical stimulation of the dorsal genital nerve for treatment of urge incontinence in patients with non-neurogenic bladder. Able-bodied women with urge incontinence and without primary stress incontinence, urinary tract infection, allergy to local anesthetic, or a demand-type pacemaker are eligible. Subjects will have their bladder volumes and pressures tested with and without low-level electrical stimulation of sensory nerves. Subjects who are appropriate candidates will be offered the use of electrical stimulation at home while recording their incontinence in a diary. Stimulation will be applied over the pubic symphysis using skin surface electrodes or coiled fine wire percutaneous electrodes inserted via a needle under the skin and attached to a commercially available battery-powered portable stimulator. This research is expected to be significant to the development of techniques and technology to temporarily reduce symptoms of incontinence and medication usage.
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