This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The investigators propose to compare the 'potential beneficial effects' of two contraceptive pills in the prevention of lactation induced demineralization. Lactation causes demineralization in most Caucasian women. Although demineralization is thought to be reversible upon discontinuation of lactating, this may not universally occur particularly in athletes and others with compromised skeletal systems. The investigators hypothesize that an estrogen-containing agent should be more effective. A randomized study is proposed to compare Loestrin (an estrogen-containing agent) with Micronov (a progesterone agent). Contraceptives will be administered in the normal dose from 4 weeks to 6 months post-delivery. Bone mineralization will be assessed by DEXA on both the mother and infant at the onset of contraception therapy and at 6 months post-delivery. Bone related hormonal analysis and body composition will also be determined at these times. Dietary calcium intake and exercise history will be collected.
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