This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The 'Type 1 Diabetes Genetics Consortium' (T1DGC) proposes to organize international efforts to identify genes that determine an individual's risk of type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The creation of a resource-base of well-characterized families from multiple ethnic groups is proposed that will facilitate the localization and characterization of type 1 diabetes genes based on statistically powered genome-wide linkage studies. Building upon these Consortium resources, members and collaborators of the Consortium will be able to undertake molecular genetic studies to identify individual genes that determine susceptibility or protection. The ultimate goal is to provide the fundamental clinical and genetic resources to achieve the necessary sample size and sample availability for gene identification. The Consortium will establish a mechanism to ensure that scientists work together toward a better understanding of the genetic factors that underlies risk for type 1 diabetes. The Consortium will gain a better understanding of disease mechanisms, with a purpose of altering these mechanisms and pathways in individuals at risk of type 1 diabetes. The T1DGC will collect information and blood samples from sib-pair and trio families located in five study-defined geographic areas worldwide: Asia-Pacific, Europe, Latin America, North America, and the United Kingdom. In North America, only affected sib-pair (ASP) families will be recruited and are, at a minimum, comprised of just two affected siblings, although emphasis will be placed on collecting the larger family unit (two type 1 diabetic siblings, their parents, and +/- up to two non-diabetic siblings).
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