This protocol compares the disposition kinetics of natural (unlabeled cotinine) and deuterium-labeled cotinine; compares the rates of metabolism of deuterium-labeled nicotine in low doses in smokers and non-smokers; and studies the pharmacokinetics of nicotine and cotinine, making use of a combined infusion of labeled compounds in subjects of different ages and gender.

Project Start
Project End
Budget Start
Budget End
Support Year
34
Fiscal Year
1996
Total Cost
Indirect Cost
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