The study is a four-part"""""""" open-label, Phase I, 8 week drug interaction study. Parts A and B will examine the effects of fluconazole and rifabutin or clarithromycin, together and alone, on the pharmacokinetics of sulfamethoxazole (SMX). Parts C and D will examine the effects of fluconazole and rifabutin or clarithromycin, together and alone, on the pharmacokinetics of dapsone.
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