The GCRC at San Francisco General Hospital (SFGH) is now in its 35th year of continuous funding, This renewal application comes three years after the unit moved from an isolated building to the main hospital facility, stimulating considerable interest in the use of the GCRC by a diverse group of investigators who wish to study patients at a high acuity level than we previously possible. Last year we added a separate outpatient clinic to accommodate a rapidly expanding number of protocols that require such a facility. A total of 36 PIs, representing 9 departments, have submitted 68 protocols. Our program is highly diverse, ranging from classic metabolic studies to pharmacokinetics, controlled drug infusions, and a variety of therapeutic trials. As befits a program located at SFGH, AIDS is well represented with am emphasis on pathophysiological mechanisms as well as therapeutics. Examples of studies proposed in this application include: effects of viral infection and multi-day exposure to zone in asthma; fluoxetine and cue-reactivity in amphetamine users; effects of carbon monoxide on the cardiovascular system; clinical pharmacology of nicotine; pathogenesis of low HDL levels in Turks; HIV vaccine trial in healthy adults; salvage therapy for multi-drug resistent TB; gene expression in G protein receptor signaling; HIV-1 protease genotypic resistance patterns; zinc, glucocorticoids and immune function in ESRD; hedgehog signaling pathway in cancers; utilization of health services in Latino women and infants; lymphocyte depletion following HIV infection: malabsorption and energy deficit in AIDS wasting: effect of hypertriglyceridemia on endotoxemia; effectiveness of protease inhibitors in practice; LDL subclass patterns and high carbohydrate diet; hepatic metabolic pathways in NIDDM; metabolic effects of alcohol ingestion; kinetics of circulating HIV and CD4+ cells; de novo nephropathy; markers of acute lung injury in trauma patients; the role of the thymus in HIV disease; viral burden, altered metabolism, and HIV wasting; anabolic and anti-cytokine therapies and their metabolic effects in AIDS; anabolic therapy, amelioration of acidosis and resistance exercise in ESRD; mitigation of episodic wasting in HIV infection. Included in this proposal are expanded activities for and plans to renovate the core laboratory and a new initiative to expand training capabilities in patient-oriented research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000083-36
Application #
2442060
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1974-10-01
Project End
2002-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
36
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Scherzer, Rebecca; Heymsfield, Steven B; Rimland, David et al. (2017) Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection. AIDS 31:71-79
Abid, Z; Oh, S S; Hu, D et al. (2016) Maternal age and asthma in Latino populations. Clin Exp Allergy 46:1398-1406
Rahmani, Elior; Zaitlen, Noah; Baran, Yael et al. (2016) Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies. Nat Methods 13:443-5
Morrissey, Kari M; Stocker, Sophie L; Chen, Eugene C et al. (2016) The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet 55:495-506
Wright, Patrick W; Pyakurel, Ashmit; Vaida, Florin F et al. (2016) Putamen volume and its clinical and neurological correlates in primary HIV infection. AIDS 30:1789-94
Peters, Marion G; Bacchetti, Peter; Boylan, Ross et al. (2016) Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV. AIDS 30:723-9
Gonzales, C A; Bacchetti, P; Khalili, M (2016) Impact of gender and menopausal status on metabolic parameters in chronic hepatitis C infection. J Viral Hepat 23:232-9
Siewe, Basile; Pham, Joey T; Cohen, Mardge et al. (2015) Dysregulated B-cell TLR2 expression and elevated regulatory B-cell frequency precede the diagnosis of AIDS-related non-Hodgkin lymphoma. AIDS 29:1659-64
Andreae, Michael H; Carter, George M; Shaparin, Naum et al. (2015) Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data. J Pain 16:1221-1232

Showing the most recent 10 out of 553 publications