Abstract

A prospective, correlational, repeated measures design will be used to evaluate the immune status of trauma patients. A combination of assays including serial assessment of serum complement C3 level, measurement of delayed type hypersensitivity skin response, and the differentiation of immune cell functional profile through the characterization of immune cell phenotypic responses to stimuli will be performed on patients sustaining moderate to severe injury.
The specific aim of the study is to determine if early measurement of an immune cell functional profile is as effective as the measurement of delayed type hypersensitivity skin response or the measurement of serum complement C3 level in predicting the progression to systemic inflammatory response syndrome. The GCRC will be used to assist with the collection of the blood specimen tubes from 911 trauma patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000083-36
Application #
6276723
Study Section
Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
36
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Scherzer, Rebecca; Heymsfield, Steven B; Rimland, David et al. (2017) Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection. AIDS 31:71-79
Wright, Patrick W; Pyakurel, Ashmit; Vaida, Florin F et al. (2016) Putamen volume and its clinical and neurological correlates in primary HIV infection. AIDS 30:1789-94
Peters, Marion G; Bacchetti, Peter; Boylan, Ross et al. (2016) Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV. AIDS 30:723-9
Gonzales, C A; Bacchetti, P; Khalili, M (2016) Impact of gender and menopausal status on metabolic parameters in chronic hepatitis C infection. J Viral Hepat 23:232-9
Abid, Z; Oh, S S; Hu, D et al. (2016) Maternal age and asthma in Latino populations. Clin Exp Allergy 46:1398-1406
Rahmani, Elior; Zaitlen, Noah; Baran, Yael et al. (2016) Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies. Nat Methods 13:443-5
Morrissey, Kari M; Stocker, Sophie L; Chen, Eugene C et al. (2016) The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet 55:495-506
Siewe, Basile; Pham, Joey T; Cohen, Mardge et al. (2015) Dysregulated B-cell TLR2 expression and elevated regulatory B-cell frequency precede the diagnosis of AIDS-related non-Hodgkin lymphoma. AIDS 29:1659-64
Andreae, Michael H; Carter, George M; Shaparin, Naum et al. (2015) Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data. J Pain 16:1221-1232

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